BAIT

CND3

SPCC188.03
condensin complex non-SMC subunit Cnd3
GO Process (1)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

MAD2

SPBC20F10.06
mitotic spindle checkpoint protein Mad2
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Condensin HEAT subunits required for DNA repair, kinetochore/centromere function and ploidy maintenance in fission yeast.

Xu X, Nakazawa N, Yanagida M

Condensin, a central player in eukaryotic chromosomal dynamics, contains five evolutionarily-conserved subunits. Two SMC (structural maintenance of chromosomes) subunits contain ATPase, hinge, and coiled-coil domains. One non-SMC subunit is similar to bacterial kleisin, and two other non-SMC subunits contain HEAT (similar to armadillo) repeats. Here we report isolation and characterization of 21 fission yeast (Schizosaccharomyces pombe) mutants for three non-SMC ... [more]

PLoS ONE Mar. 13, 2015; 10(3);e0119347 [Pubmed: 25764183]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Curated By

  • BioGRID