NDC80
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DIS2
Gene Ontology Biological Process
- mitotic DNA damage checkpoint [IGI]
- mitotic sister chromatid segregation [IMP]
- positive regulation of establishment of cell polarity regulating cell shape [EXP]
- positive regulation of protein localization to cell tip [EXP]
- rRNA processing [ISO]
- regulation of mitotic sister chromatid segregation [IMP]
- signal transduction [NAS]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.
Upon establishment of proper kinetochore-microtubule attachment, the spindle assembly checkpoint (SAC) must be silenced to allow onset of anaphase, which is when sister chromatids segregate equally to two daughter cells. However, how proper kinetochore-microtubule attachment leads to timely anaphase onset remains elusive. Furthermore, the molecular mechanisms of chromosome movement during anaphase A remain unclear. In this study, we show that ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NDC80 DIS2 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 2334532 |
Curated By
- BioGRID