BAIT
CSN1
SPBC215.03c
COP9/signalosome complex subunit Csn1
GO Process (4)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Schizosaccharomyces pombe (972h)
PREY
WEE1
SPCC18B5.03
M phase inhibitor protein kinase Wee1
GO Process (8)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cytokinesis after mitosis checkpoint [IGI]
- mitotic DNA damage checkpoint [IMP]
- mitotic cell cycle checkpoint [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IDA]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-tyrosine autophosphorylation [IDA]
- regulation of cell size [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway.
In meiosis, the fission yeast nucleus displays an elongated morphology, moving back and forth within the cell; these nuclear movements continue for approximately 2Â h before meiotic nuclear divisions. Meiotic DNA replication occurs in an early phase of the nuclear movements and is followed by meiotic prophase. Here we report that in mutants deficient in meiotic DNA replication, the duration of ... [more]
Genes Cells Mar. 01, 2015; 20(3);160-72 [Pubmed: 25492408]
Throughput
- Low Throughput
Ontology Terms
- phenotype: viability (APO:0000111)
Additional Notes
- deletion of mik1/wee1 in a csn1 background is lethal
Curated By
- BioGRID