CRE2, SSN20, chromatin-remodeling histone chaperone SPT6, L000002032, YGR116W
Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region; required for H3K36 trimethylation but not dimethylation by Set2p
Saccharomyces cerevisiae (S288c)


MPG1, SRB1, VIG9, mannose-1-phosphate guanylyltransferase, L000002625, L000002860, L000002049, YDL055C
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
GO Process (3)
GO Function (1)
GO Component (1)
Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.

Gomez-Herreros F, Margaritis T, Rodriguez-Galan O, Pelechano V, Begley V, Millan-Zambrano G, Morillo-Huesca M, Munoz-Centeno MC, Perez-Ortin JE, de la Cruz J, Holstege FCP, Chavez S

Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA polymerases. Transcription elongation involves dynamic interactions between RNA polymerases and chromatin. We performed a synthetic lethal screening in Saccharomyces cerevisiae with a conditional allele of SPT6, which encodes one of the factors that facilitates this process. Some of these synthetic mutants corresponded ... [more]

Nucleic Acids Res. Jun. 15, 2017; (); [Pubmed: 28637236]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • spt6-140

Curated By

  • BioGRID