RAD51
Gene Ontology Biological Process
- double-strand break repair via homologous recombination [ISS]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IGI]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA repair synthesis [IMP]
- meiotic gene conversion [IDA]
- mitotic recombination [IGI]
- strand invasion [IDA]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RQH1
Gene Ontology Biological Process
- DNA duplex unwinding [IDA]
- cellular response to DNA damage stimulus [IMP]
- double-strand break repair via homologous recombination [IGI]
- intra-S DNA damage checkpoint [IDA]
- maintenance of rDNA [IMP]
- mitotic DNA replication DNA duplex unwinding [ISO]
- negative regulation of mitotic recombination [IMP]
- postreplication repair [IMP]
- recombinational repair [IGI]
- regulation of mitotic recombination involved in replication fork processing [IMP]
- replication fork processing at rDNA locus [IGI]
- resolution of mitotic recombination intermediates [IMP]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The RecQ DNA helicase Rqh1 constrains Exonuclease 1-dependent recombination at stalled replication forks.
DNA double-strand break (DSB) repair by homologous recombination (HR) involves resection of the break to expose a 3' single-stranded DNA tail. In budding yeast, resection occurs in two steps: initial short-range resection, performed by Mre11-Rad50-Xrs2 and Sae2; and long-range resection catalysed by either Exo1 or Sgs1-Dna2. Here we use genetic assays to investigate the importance of Exo1 and the Sgs1 ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome/plasmid maintenance (APO:0000143)
Additional Notes
- deletion of exo1 and rqh1 suppresses the increase in deletions seen in a rad51 mutant
- genetic complex
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RQH1 RAD51 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 816416 | |
| RAD51 RQH1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 875247 | |
| RAD51 RQH1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 449586 | |
| RQH1 RAD51 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 247868 | |
| RQH1 RAD51 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 436307 | |
| RQH1 RAD51 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | High | - | PomBase | - | |
| RQH1 RAD51 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 248080 | |
| RQH1 RAD51 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 429942 | |
| RQH1 RAD51 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 816369 | |
| RQH1 RAD51 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 248119 | |
| RQH1 RAD51 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 1032161 | |
| RQH1 RAD51 | Synthetic Rescue Synthetic Rescue A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene. | Low | - | BioGRID | 2327765 |
Curated By
- BioGRID