BAIT
DNA2
DNA2L, hDNA2, RP11-9E13.1
DNA replication helicase/nuclease 2
GO Process (17)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- ATP catabolic process [IDA, TAS]
- DNA catabolic process, endonucleolytic [IDA]
- DNA double-strand break processing [IDA]
- DNA duplex unwinding [IDA]
- DNA replication [IMP]
- DNA replication checkpoint [IMP]
- DNA replication, Okazaki fragment processing [IDA]
- DNA replication, removal of RNA primer [IDA]
- DNA strand elongation involved in DNA replication [TAS]
- base-excision repair [IDA]
- mitochondrial DNA repair [IDA]
- mitochondrial DNA replication [IDA]
- mitotic cell cycle [TAS]
- positive regulation of DNA replication [IDA]
- telomere maintenance [TAS]
- telomere maintenance via recombination [TAS]
- telomere maintenance via semi-conservative replication [TAS]
Gene Ontology Molecular Function- 5'-3' DNA helicase activity [IDA]
- 5'-flap endonuclease activity [IDA]
- ATPase activity [TAS]
- DNA binding [IDA]
- DNA helicase activity [IDA]
- helicase activity [TAS]
- nuclease activity [IDA]
- protein binding [IPI]
- single-stranded DNA-dependent ATPase activity [IDA]
- site-specific endodeoxyribonuclease activity, specific for altered base [IDA]
- 5'-3' DNA helicase activity [IDA]
- 5'-flap endonuclease activity [IDA]
- ATPase activity [TAS]
- DNA binding [IDA]
- DNA helicase activity [IDA]
- helicase activity [TAS]
- nuclease activity [IDA]
- protein binding [IPI]
- single-stranded DNA-dependent ATPase activity [IDA]
- site-specific endodeoxyribonuclease activity, specific for altered base [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
EXO1
HEX1, hExoI, RP11-553N16.2
exonuclease 1
GO Process (7)
GO Function (9)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- 5'-3' exodeoxyribonuclease activity [IDA]
- 5'-3' exonuclease activity [ISS]
- DNA binding [IDA]
- RNA-DNA hybrid ribonuclease activity [TAS]
- double-stranded DNA 5'-3' exodeoxyribonuclease activity [IDA]
- exonuclease activity [TAS]
- flap endonuclease activity [IDA]
- protein binding [IPI]
- single-stranded DNA 5'-3' exodeoxyribonuclease activity [IDA]
- 5'-3' exodeoxyribonuclease activity [IDA]
- 5'-3' exonuclease activity [ISS]
- DNA binding [IDA]
- RNA-DNA hybrid ribonuclease activity [TAS]
- double-stranded DNA 5'-3' exodeoxyribonuclease activity [IDA]
- exonuclease activity [TAS]
- flap endonuclease activity [IDA]
- protein binding [IPI]
- single-stranded DNA 5'-3' exodeoxyribonuclease activity [IDA]
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network.
During DNA replication, stalled replication forks and DSBs arise when the replication fork encounters ICLs (interstrand crosslinks), covalent protein/DNA intermediates or other discontinuities in the template. Recently, homologous recombination proteins have been shown to function in replication-coupled repair of ICLs in conjunction with the Fanconi anemia (FA) regulatory factors FANCD2-FANCI, and, conversely, the FA gene products have been shown to ... [more]
Cell Cycle Nov. 01, 2012; 11(21);3983-96 [Pubmed: 22987153]
Throughput
- Low Throughput
Curated By
- BioGRID