BAIT

EGD2

L000000546, L000002606, YHR193C
Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes
UPS Project
Saccharomyces cerevisiae (S288c)
PREY

MTO1

IPS1, YGL236C
Mitochondrial protein; forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
GO Process (1)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import.

Ponce-Rojas JC, Avendano-Monsalve MC, Yanez-Falcon AR, Jaimes-Miranda F, Garay E, Torres-Quiroz F, DeLuna A, Funes S

The mitochondrial proteome is mostly composed of nuclear-encoded proteins. Such polypeptides are synthesized with signals that guide their intracellular transport to the surface of the organelle and later within the different mitochondrial sub-compartments until they reach their functional destination. It has been suggested that NAC - a cytosolic chaperone which recognizes nascent chains on translationally active ribosomes - has a ... [more]

FEBS J. Jan. 21, 2017; 0(0); [Pubmed: 28109174]

Throughput

  • Low Throughput

Ontology Terms

  • vegetative growth (APO:0000106)

Curated By

  • BioGRID