BAIT

EGD2

L000000546, L000002606, YHR193C
Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes
UPS Project
Saccharomyces cerevisiae (S288c)
PREY

SRY1

threo-3-hydroxy-L-aspartate ammonia-lyase SRY1, S000007485, YKL218C
3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
GO Process (1)
GO Function (2)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

αβ'-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import.

Ponce-Rojas JC, Avendano-Monsalve MC, Yanez-Falcon AR, Jaimes-Miranda F, Garay E, Torres-Quiroz F, DeLuna A, Funes S

The mitochondrial proteome is mostly composed of nuclear-encoded proteins. Such polypeptides are synthesized with signals that guide their intracellular transport to the surface of the organelle and later within the different mitochondrial sub-compartments until they reach their functional destination. It has been suggested that NAC - a cytosolic chaperone which recognizes nascent chains on translationally active ribosomes - has a ... [more]

FEBS J. Jan. 21, 2017; 0(0); [Pubmed: 28109174]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SRY1 EGD2
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1778BioGRID
393275

Curated By

  • BioGRID