BAIT
CNKSR2
C030004A01, Cnk2, Ksr2, mKIAA0902, RP23-93M14.3
connector enhancer of kinase suppressor of Ras 2
GO Process (1)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CAMK2B
RP23-340E18.5
calcium/calmodulin-dependent protein kinase II, beta
GO Process (17)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- activation of meiosis involved in egg activation [IMP]
- calcium ion transport [IMP]
- cell projection morphogenesis [ISO]
- inhibitory G-protein coupled receptor phosphorylation [IDA]
- long-term synaptic potentiation [ISO]
- neuromuscular process controlling balance [IMP]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of dendritic spine morphogenesis [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of phospholipase A2 activity [ISO]
- positive regulation of synapse maturation [ISO]
- protein autophosphorylation [IMP, ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of synaptic transmission, cholinergic [IMP]
- response to cadmium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
- Adult-non postsynaptic density (PSD)
Curated By
- BioGRID