BAIT
CNKSR2
C030004A01, Cnk2, Ksr2, mKIAA0902, RP23-93M14.3
connector enhancer of kinase suppressor of Ras 2
GO Process (1)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MINK1
B55, MINK, Map4k6, Ysk2, DN-183N8.7
misshapen-like kinase 1 (zebrafish)
GO Process (14)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- dendrite morphogenesis [ISO]
- intracellular signal transduction [IBA, IDA]
- negative thymic T cell selection [IMP]
- positive regulation of JNK cascade [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, IDA]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO]
- regulation of cell migration [ISO]
- regulation of cell-cell adhesion [ISO]
- regulation of cell-matrix adhesion [ISO]
- response to stress [IDA]
- signal transduction by phosphorylation [IBA]
- synaptic transmission [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
- Adult-non postsynaptic density (PSD)
Curated By
- BioGRID