BAIT
CYFIP1
E030028J09Rik, P140SRA-1, P140sra1, Shyc, Sra-1, Sra1, l(7)1Rl, l71Rl, l7Rl1, mKIAA0068, pl-1
cytoplasmic FMR1 interacting protein 1
GO Process (5)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
P2RX7
AI467586, P2X(7), P2X7R
purinergic receptor P2X, ligand-gated ion channel, 7
GO Process (72)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- NAD transport [IMP]
- T cell homeostasis [IMP]
- T cell proliferation [IMP]
- activation of MAPK activity [IMP]
- bleb assembly [IMP, ISO]
- calcium ion transport [IMP]
- cation transmembrane transport [IMP, ISO]
- cation transport [IMP, ISO]
- cell morphogenesis [IMP]
- cell volume homeostasis [IDA]
- cellular response to extracellular stimulus [IMP]
- cellular response to organic cyclic compound [IDA]
- ceramide biosynthetic process [IDA]
- collagen metabolic process [IMP]
- cytolysis [IDA, IMP]
- defense response to Gram-positive bacterium [IMP]
- extrinsic apoptotic signaling pathway [IMP]
- gene expression [IMP]
- homeostasis of number of cells within a tissue [IMP]
- inflammatory response [IMP]
- membrane budding [IMP]
- membrane depolarization [ISO]
- membrane protein ectodomain proteolysis [IMP]
- mitochondrion organization [IDA]
- multicellular organismal protein catabolic process [IDA]
- negative regulation of MAPK cascade [IDA]
- negative regulation of bone resorption [IMP]
- phagolysosome assembly [IMP]
- phospholipid transfer to membrane [IMP]
- phospholipid translocation [IDA]
- plasma membrane organization [IDA]
- pore complex assembly [IMP, ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of T cell mediated cytotoxicity [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of bone mineralization [IMP]
- positive regulation of calcium ion transport into cytosol [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cytokine secretion [IMP]
- positive regulation of gamma-aminobutyric acid secretion [IMP]
- positive regulation of glutamate secretion [IMP]
- positive regulation of interleukin-1 alpha secretion [IMP]
- positive regulation of interleukin-1 beta production [IMP]
- positive regulation of interleukin-1 beta secretion [IMP, ISO]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of lymphocyte apoptotic process [IMP]
- positive regulation of mitochondrial depolarization [IMP]
- positive regulation of ossification [IMP]
- positive regulation of prostaglandin secretion [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein secretion [IDA]
- programmed cell death [IDA, IMP]
- protein oligomerization [IDA]
- protein phosphorylation [IMP]
- protein processing [IMP]
- purinergic nucleotide receptor signaling pathway [IBA, ISO]
- reactive oxygen species metabolic process [IMP]
- release of sequestered calcium ion into cytosol [IMP]
- response to ATP [IDA, IMP, ISO]
- response to bacterium [IMP]
- response to calcium ion [IDA, IMP]
- response to drug [IMP]
- response to electrical stimulus [IMP]
- response to fluid shear stress [IMP]
- response to lipopolysaccharide [IDA, IMP]
- response to mechanical stimulus [IMP]
- response to organic cyclic compound [IDA]
- response to organic substance [IMP]
- response to zinc ion [IMP]
- sensory perception of pain [IMP]
- skeletal system morphogenesis [IMP]
- synaptic vesicle exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell-cell junction [IDA]
- cytosol [IMP]
- external side of plasma membrane [IDA]
- integral component of nuclear inner membrane [IBA]
- integral component of plasma membrane [IMP, ISS]
- intracellular [IMP]
- membrane [IDA, ISO]
- neuromuscular junction [IDA]
- neuronal cell body [IDA]
- plasma membrane [IDA, ISO]
- synapse [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID