BAIT
CYFIP1
E030028J09Rik, P140SRA-1, P140sra1, Shyc, Sra-1, Sra1, l(7)1Rl, l71Rl, l7Rl1, mKIAA0068, pl-1
cytoplasmic FMR1 interacting protein 1
GO Process (5)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PICALM
CALM, CLTH, PAP180, fit-1, fit1, mKIAA4114
phosphatidylinositol binding clathrin assembly protein
GO Process (22)
GO Function (6)
GO Component (18)
Gene Ontology Biological Process
- axonogenesis [IMP, ISO]
- cargo loading into vesicle [ISO]
- cell proliferation [ISO]
- clathrin coat assembly [ISO]
- clathrin-mediated endocytosis [ISO]
- dendrite morphogenesis [IMP, ISO]
- endosomal transport [ISO]
- hemopoiesis [IMP]
- iron ion homeostasis [ISO]
- iron ion import into cell [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of receptor-mediated endocytosis [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- regulation of endocytosis [ISO]
- regulation of protein localization [ISO]
- regulation of protein transport [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-2 adaptor complex [ISO]
- clathrin coat of coated pit [ISO]
- clathrin-coated vesicle [ISO]
- coated pit [IDA, ISO]
- endosome [ISO]
- intracellular [IDA]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- neurofibrillary tangle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
- synapse [ISO]
- synaptic vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID