BAIT
CYFIP1
E030028J09Rik, P140SRA-1, P140sra1, Shyc, Sra-1, Sra1, l(7)1Rl, l71Rl, l7Rl1, mKIAA0068, pl-1
cytoplasmic FMR1 interacting protein 1
GO Process (5)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRKCE
5830406C15Rik, PKC[e], PKCepsilon, Pkce, R75156
protein kinase C, epsilon
GO Process (36)
GO Function (13)
GO Component (13)
Gene Ontology Biological Process
- TRAM-dependent toll-like receptor 4 signaling pathway [IMP]
- cellular response to ethanol [IGI]
- cellular response to hypoxia [IDA]
- cellular response to prostaglandin E stimulus [IDA]
- chemosensory behavior [TAS]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [IMP]
- locomotory exploration behavior [IGI]
- macrophage activation involved in immune response [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of mitochondrial calcium ion concentration [ISO]
- negative regulation of mitochondrial membrane potential [ISO]
- negative regulation of release of sequestered calcium ion into cytosol [ISO]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IDA, IMP]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell-substrate adhesion [IGI, IMP]
- positive regulation of cellular glucuronidation [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of fibroblast migration [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of lipid catabolic process [IMP]
- positive regulation of mucus secretion [IMP]
- positive regulation of receptor activity [IDA]
- positive regulation of synaptic transmission, GABAergic [IMP]
- positive regulation of wound healing [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- regulation of lipid metabolic process [IMP]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- regulation of release of sequestered calcium ion into cytosol [IDA]
- release of sequestered calcium ion into cytosol [IMP]
- response to morphine [IMP]
Gene Ontology Molecular Function
- 14-3-3 protein binding [IPI]
- SH3 domain binding [ISO]
- actin monomer binding [IDA]
- calcium-independent protein kinase C activity [IDA]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [IDA]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- receptor activator activity [IDA]
- receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID