BAIT
CYFIP1
E030028J09Rik, P140SRA-1, P140sra1, Shyc, Sra-1, Sra1, l(7)1Rl, l71Rl, l7Rl1, mKIAA0068, pl-1
cytoplasmic FMR1 interacting protein 1
GO Process (5)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PROX1
A230003G05Rik
prospero homeobox 1
GO Process (46)
GO Function (12)
GO Component (2)
Gene Ontology Biological Process
- acinar cell differentiation [IMP]
- aorta smooth muscle tissue morphogenesis [IMP]
- atrial cardiac muscle tissue morphogenesis [IMP]
- branching involved in pancreas morphogenesis [IMP]
- cell fate determination [IMP]
- cerebellar granule cell differentiation [IMP]
- dentate gyrus development [IMP]
- endocardium formation [IMP]
- endothelial cell differentiation [IMP]
- hepatocyte cell migration [IMP]
- hepatocyte proliferation [IMP]
- inner ear development [IMP]
- lens fiber cell morphogenesis [IMP]
- lens morphogenesis in camera-type eye [IMP]
- lymph vessel development [IMP]
- lymphangiogenesis [ISO]
- lymphatic endothelial cell differentiation [IMP, ISO]
- negative regulation of bile acid biosynthetic process [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of viral genome replication [ISO]
- neuronal stem cell maintenance [IMP]
- positive regulation of cell cycle [IMP]
- positive regulation of cell cycle checkpoint [IMP]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of forebrain neuron differentiation [IMP]
- positive regulation of heart growth [IMP]
- positive regulation of neural precursor cell proliferation [IMP]
- positive regulation of sarcomere organization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of circadian rhythm [ISO]
- regulation of gene expression [IMP, ISO]
- regulation of transcription involved in lymphatic endothelial cell fate commitment [ISO]
- regulation of transcription, DNA-templated [NAS]
- skeletal muscle thin filament assembly [IMP]
- transcription from RNA polymerase II promoter [IDA]
- venous blood vessel morphogenesis [IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- ventricular cardiac myofibril assembly [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- DBD domain binding [ISO]
- DNA binding [ISO]
- LBD domain binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- core promoter sequence-specific DNA binding [IDA]
- ligand-dependent nuclear receptor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- DBD domain binding [ISO]
- DNA binding [ISO]
- LBD domain binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- core promoter sequence-specific DNA binding [IDA]
- ligand-dependent nuclear receptor binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription corepressor activity [ISO]
- transcription regulatory region DNA binding [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID