BAIT
CYFIP1
E030028J09Rik, P140SRA-1, P140sra1, Shyc, Sra-1, Sra1, l(7)1Rl, l71Rl, l7Rl1, mKIAA0068, pl-1
cytoplasmic FMR1 interacting protein 1
GO Process (5)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAPGEF2
5830453M24Rik, CNRasGEF, Pdzgef1, RA-GEF-1, mKIAA0313, nRapGEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (32)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- Rap protein signal transduction [ISO]
- adenylate cyclase-activating adrenergic receptor signaling pathway [ISO]
- blood vessel development [IMP]
- brain-derived neurotrophic factor receptor signaling pathway [ISO]
- cAMP-mediated signaling [IDA, ISO]
- cellular response to cAMP [IDA, IMP, ISO]
- cellular response to cGMP [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- establishment of endothelial barrier [ISO]
- forebrain neuron development [IMP]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of dendrite morphogenesis [IMP, ISO]
- negative regulation of melanin biosynthetic process [IMP]
- nerve growth factor signaling pathway [ISO]
- neuron migration [IMP]
- neuron projection development [IMP, ISO]
- neuropeptide signaling pathway [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP, ISO]
- positive regulation of Rap GTPase activity [IDA, IMP, ISO]
- positive regulation of Ras GTPase activity [IMP, ISO]
- positive regulation of cAMP-dependent protein kinase activity [IMP, ISO]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of dendritic cell apoptotic process [IMP, ISO]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein binding [IDA]
- positive regulation of protein kinase activity [IDA, ISO]
- positive regulation of vasculogenesis [IMP]
- regulation of cell junction assembly [ISO]
- regulation of synaptic plasticity [ISO]
- ventricular system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID