BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MYO5A
9630007J19Rik, AI413174, AI661011, Dbv, MVa, Myo5, MyoVA, Sev-1, d, d-120J, flail, flr, RP24-189I2.1
myosin VA
GO Process (29)
GO Function (15)
GO Component (29)
Gene Ontology Biological Process
- actin filament-based movement [IDA, ISO]
- anagen [IMP]
- cellular response to insulin stimulus [IMP]
- developmental pigmentation [IMP]
- endoplasmic reticulum localization [IMP]
- exocytosis [IMP]
- insulin secretion [IMP]
- locomotion involved in locomotory behavior [IMP]
- long-chain fatty acid biosynthetic process [IMP]
- melanin biosynthetic process [IMP]
- melanin metabolic process [IMP]
- melanocyte differentiation [IMP]
- melanosome localization [IMP]
- melanosome transport [IDA, IMP]
- metabolic process [ISO]
- myelination [IMP]
- neuromuscular process controlling balance [IMP]
- odontogenesis [IDA]
- pigmentation [IMP, ISA]
- post-Golgi vesicle-mediated transport [ISO]
- protein localization to plasma membrane [IMP]
- regulation of exocytosis [ISO]
- regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IMP]
- secretory granule localization [IMP, ISO]
- synapse organization [IMP]
- synaptic transmission [IMP]
- vesicle transport along actin filament [ISO, TAS]
- vesicle-mediated transport [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATP-dependent protein binding [ISO]
- Rab GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [IDA]
- calcium ion binding [IDA]
- calcium-dependent protein binding [ISO]
- calmodulin binding [IDA]
- microfilament motor activity [IDA, ISO]
- motor activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- syntaxin-1 binding [ISO]
- ATP binding [ISO]
- ATP-dependent protein binding [ISO]
- Rab GTPase binding [IPI, ISO]
- SNARE binding [ISO]
- actin binding [IDA]
- calcium ion binding [IDA]
- calcium-dependent protein binding [ISO]
- calmodulin binding [IDA]
- microfilament motor activity [IDA, ISO]
- motor activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- actin filament [ISO]
- actomyosin [IDA]
- actomyosin, myosin complex part [ISO]
- axon [ISO]
- cell [IMP]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- filopodium tip [ISO]
- insulin-responsive compartment [IDA]
- intermediate filament [IDA]
- late endosome [ISO]
- lysosome [ISO]
- melanosome [IDA]
- membrane [ISO]
- microtubule plus-end [IDA]
- myosin complex [IDA]
- neuron projection [ISO]
- neuronal cell body [IDA, ISO]
- peroxisome [ISO]
- photoreceptor outer segment [IDA]
- recycling endosome [ISO]
- ruffle [ISO]
- secretory granule [IDA, ISO]
- synaptic vesicle [ISO]
- vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
- Adult postsynaptic density (PSD)
Curated By
- BioGRID