CYFIP2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NCKAP1
Gene Ontology Biological Process
- Rac protein signal transduction [ISO]
- apical protein localization [IDA]
- basal protein localization [IDA]
- cell migration involved in gastrulation [IMP]
- embryonic body morphogenesis [IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic heart tube development [IMP]
- endoderm development [IMP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- in utero embryonic development [IMP]
- lamellipodium assembly [IDA, IMP]
- mesodermal cell migration [IMP]
- neural tube closure [IMP]
- notochord development [IMP]
- notochord morphogenesis [IMP]
- paraxial mesoderm development [IMP]
- paraxial mesoderm morphogenesis [IMP]
- positive regulation of Arp2/3 complex-mediated actin nucleation [ISO]
- positive regulation of lamellipodium assembly [ISO]
- protein stabilization [IMP]
- regulation of protein localization [IMP]
- somitogenesis [IMP]
- zygotic determination of anterior/posterior axis, embryo [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
- Adult postsynaptic density (PSD)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CYFIP2 NCKAP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| NCKAP1 CYFIP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2340371 | |
| NCKAP1 CYFIP2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.7925 | BioGRID | 2668352 |
Curated By
- BioGRID