BAIT
CYFIP2
1500004I01Rik, 6430511D02Rik, AA930218, AU022376, Pir121, mKIAA1168, RP23-370F7.1
cytoplasmic FMR1 interacting protein 2
GO Process (4)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NLGN3
A230085M13Rik, HNL3, NL3, RP23-440J15.4
neuroligin 3
GO Process (28)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- adult behavior [ISO]
- axon extension [ISO]
- learning [ISO]
- neuron cell-cell adhesion [IBA, ISO]
- oligodendrocyte differentiation [IMP]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of synapse assembly [ISO]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic membrane assembly [IMP]
- presynaptic membrane assembly [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of inhibitory postsynaptic membrane potential [IMP, ISO]
- regulation of long-term synaptic potentiation [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IGI]
- regulation of synaptic transmission [IGI]
- regulation of synaptic transmission, glutamatergic [IMP]
- regulation of terminal button organization [IMP]
- rhythmic synaptic transmission [ISO]
- social behavior [IMP, ISO]
- synapse assembly [ISO]
- synapse organization [IGI, ISO]
- visual learning [IMP]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID