BAIT
BIR1
L000004754, YJR089W
Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog
GO Process (5)
GO Function (0)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
PGM2
GAL5, phosphoglucomutase PGM2, L000001413, YMR105C
Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication
GO Process (8)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- UDP-glucose metabolic process [IGI]
- cellular calcium ion homeostasis [IGI, IMP]
- cellular cation homeostasis [IMP]
- galactose catabolic process [IGI, IMP]
- glucose 1-phosphate metabolic process [IGI, IMP, ISS]
- glucose 6-phosphate metabolic process [ISS]
- glycogen biosynthetic process [IGI]
- trehalose biosynthetic process [IGI]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A Functional Link Between Bir1 and the Saccharomyces cerevisiae Ctf19 Kinetochore Complex Revealed Through Quantitative Fitness Analysis.
The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here, we report a genome-wide genetic interaction screen in Saccharomyces cerevisiae using the bir1-17 mutant, identifying through quantitative fitness analysis deletion mutations that act as enhancers and ... [more]
G3 (Bethesda) Sep. 07, 2017; 7(9);3203-3215 [Pubmed: 28754723]
Quantitative Score
- -11.4 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: fitness (APO:0000216)
Additional Notes
- authors define fitness as the maximum double rate x maximum doubling potential, 37C
Curated By
- BioGRID