BAIT
FXR1
1110050J02Rik, 9530073J07Rik, AI851072, Fxr1h, Fxr1p
fragile X mental retardation gene 1, autosomal homolog
GO Process (2)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
CDH2
CDHN, N-cadherin, Ncad
cadherin 2
GO Process (19)
GO Function (9)
GO Component (15)
Gene Ontology Biological Process
- blood vessel morphogenesis [IMP]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell-cell adhesion mediated by cadherin [IDA]
- glial cell differentiation [IDA]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- negative regulation of canonical Wnt signaling pathway [IGI]
- neuronal stem cell maintenance [IDA]
- positive regulation of MAPK cascade [IGI]
- protein heterooligomerization [ISO]
- regulation of Rho protein signal transduction [ISO]
- regulation of axonogenesis [ISO]
- regulation of myelination [ISO]
- regulation of protein localization [ISO]
- single organismal cell-cell adhesion [ISO]
- striated muscle cell differentiation [IGI]
- synapse assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- adherens junction [IDA]
- apical plasma membrane [IDA]
- catenin complex [ISO]
- cell-cell adherens junction [ISO]
- cell-cell junction [IDA, ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- intercalated disc [IDA, ISO]
- lamellipodium [IDA]
- membrane [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
- e14
Curated By
- BioGRID