BAIT
FXR1
1110050J02Rik, 9530073J07Rik, AI851072, Fxr1h, Fxr1p
fragile X mental retardation gene 1, autosomal homolog
GO Process (2)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PAK2
5330420P17Rik, A130002K10Rik, AI836325, D16Ertd269e, PAK-2, mKIAA4182
p21 protein (Cdc42/Rac)-activated kinase 2
GO Process (15)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- cytokinesis [IBA]
- intracellular signal transduction [IBA]
- mitotic cell cycle [IBA]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO, ISS]
- regulation of apoptotic process [IBA]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IBA, ISO]
- nucleoplasm [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
- e14
Curated By
- BioGRID