BAIT
FXR1
1110050J02Rik, 9530073J07Rik, AI851072, Fxr1h, Fxr1p
fragile X mental retardation gene 1, autosomal homolog
GO Process (2)
GO Function (4)
GO Component (10)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
SCRIB
AI118201, CRIB, Crc, SCRIB1, Scrb1, mKIAA0147, vartul
scribbled homolog (Drosophila)
GO Process (22)
GO Function (1)
GO Component (13)
Gene Ontology Biological Process
- activation of Rac GTPase activity [ISO]
- apoptotic process involved in morphogenesis [ISO]
- astrocyte cell migration [ISO]
- asymmetric protein localization [IMP]
- auditory receptor cell morphogenesis [IGI]
- auditory receptor cell stereocilium organization [IGI]
- cell migration [IMP, ISO]
- cell proliferation [ISO]
- cochlear nucleus development [IGI]
- establishment of apical/basal cell polarity [ISO]
- mammary gland duct morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of mitotic cell cycle [ISO]
- neural tube closure [IMP, ISO]
- positive chemotaxis [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of receptor recycling [ISO]
- protein localization to adherens junction [ISO]
- single organismal cell-cell adhesion [ISO]
- synaptic vesicle endocytosis [IMP]
- synaptic vesicle targeting [IMP]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [ISO]
- basolateral plasma membrane [IDA]
- cell [IMP]
- cell leading edge [ISO]
- cell-cell adherens junction [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- myelin sheath abaxonal region [IDA]
- nucleoplasm [ISO]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- e14
Curated By
- BioGRID