BAIT
HCN1
Bcng1, C630013B14Rik, HAC2
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAPK8IP2
3230402N03Rik, AI847694, AW049958, IB2, Jip2, R75148
mitogen-activated protein kinase 8 interacting protein 2
GO Process (15)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- JNK cascade [IDA]
- MAPK cascade [ISO]
- behavioral fear response [IMP]
- dendrite morphogenesis [IMP]
- mating behavior [IMP]
- nonassociative learning [IMP]
- positive regulation of protein kinase activity [ISO]
- positive regulation of stress-activated MAPK cascade [ISO]
- regulation of JNK cascade [ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of receptor activity [IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- social behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
Curated By
- BioGRID