BAIT
HCN1
Bcng1, C630013B14Rik, HAC2
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NF1
AW494271, E030030H24Rik, Nf-1, RP23-188A3.1
neurofibromatosis 1
GO Process (66)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- Ras protein signal transduction [IGI, IMP]
- Schwann cell development [IMP]
- actin cytoskeleton organization [IGI, IMP]
- adrenal gland development [IMP]
- artery morphogenesis [IMP]
- brain development [IMP]
- camera-type eye morphogenesis [IMP]
- cell communication [IMP]
- cerebral cortex development [IMP]
- cognition [ISO]
- collagen fibril organization [IMP]
- extracellular matrix organization [IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI]
- forebrain astrocyte development [IMP]
- forebrain morphogenesis [IMP]
- heart development [IMP]
- liver development [IMP]
- metanephros development [IMP]
- myelination in peripheral nervous system [IMP]
- negative regulation of MAP kinase activity [IGI, IMP]
- negative regulation of MAPK cascade [IMP, ISO]
- negative regulation of Rac protein signal transduction [IGI]
- negative regulation of Ras protein signal transduction [IGI, IMP]
- negative regulation of angiogenesis [IGI]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of cell migration [IGI, IMP, ISO]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of cell-matrix adhesion [IGI]
- negative regulation of endothelial cell proliferation [IMP, ISO]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of neuroblast proliferation [IMP]
- negative regulation of neurotransmitter secretion [IGI, IMP]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IGI]
- negative regulation of protein kinase activity [IGI, IMP]
- negative regulation of transcription factor import into nucleus [IMP]
- neural tube development [IGI]
- osteoblast differentiation [IMP]
- peripheral nervous system development [IMP]
- phosphatidylinositol 3-kinase signaling [IMP]
- pigmentation [IGI, IMP]
- positive regulation of Ras GTPase activity [IGI, IMP, ISO]
- positive regulation of adenylate cyclase activity [IMP]
- positive regulation of apoptotic process [IGI, IMP]
- positive regulation of endothelial cell proliferation [IGI]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- positive regulation of neuron apoptotic process [IGI, IMP]
- regulation of Ras GTPase activity [ISO]
- regulation of angiogenesis [IMP, ISO]
- regulation of blood vessel endothelial cell migration [ISO]
- regulation of bone resorption [IMP]
- regulation of cell proliferation [IGI]
- regulation of cell-matrix adhesion [IMP]
- regulation of glial cell differentiation [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of neuron differentiation [ISO]
- regulation of synaptic transmission, GABAergic [IGI]
- response to hypoxia [IMP]
- skeletal muscle tissue development [IMP]
- smooth muscle tissue development [IMP]
- spinal cord development [IMP]
- sympathetic nervous system development [IMP]
- visual learning [IGI, IMP]
- wound healing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
Curated By
- BioGRID