BAIT
HCN1
Bcng1, C630013B14Rik, HAC2
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PAK3
PAK-3, Pak65alpha, Pak65beta, Stk4, RP23-45O6.1
p21 protein (Cdc42/Rac)-activated kinase 3
GO Process (14)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [IBA]
- activation of MAPK activity [ISO]
- axonogenesis [IMP]
- dendrite development [IMP]
- intracellular signal transduction [IBA]
- positive regulation of DNA biosynthetic process [ISO]
- positive regulation of dendritic spine morphogenesis [ISO]
- positive regulation of neuron apoptotic process [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of actin filament polymerization [ISO]
- regulation of neuron projection development [ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
Curated By
- BioGRID