BAIT

HERC2

D15F32S1h, D7H15F32S1, D7H15F37S1, jdf2, mKIAA0393, rjs

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2

GO Process (5)

GO Function (3)

GO Component (4)

Gene Ontology Biological Process

DNA repair [ISO]

cellular response to DNA damage stimulus [ISO]

protein ubiquitination [ISO]

protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]

spermatogenesis [IMP]

Gene Ontology Molecular Function

SUMO binding [ISO]
ubiquitin protein ligase binding [ISO]
ubiquitin-protein transferase activity [IBA, ISO]

Gene Ontology Cellular Component

cytoplasm [ISO]

mitochondrial inner membrane [IDA]

nucleus [IBA, ISO]

CRISPR Database MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

TRP53BP1

53BP1, Tp53bp1, m53BP1, p53BP1, RP23-437L13.2

transformation related protein 53 binding protein 1

GO Process (5)

GO Function (9)

GO Component (6)

Gene Ontology Biological Process

DNA repair [IDA]

cellular response to DNA damage stimulus [ISO]

positive regulation of transcription from RNA polymerase II promoter [ISO]

regulation of transcription, DNA-templated [TAS]

transcription from RNA polymerase II promoter [ISO]

Gene Ontology Molecular Function

RNA polymerase II activating transcription factor binding [ISO]
RNA polymerase II transcription cofactor activity [ISO]
damaged DNA binding [IDA]
methylated histone binding [ISO]
p53 binding [ISO]
protein binding [IPI]
sequence-specific DNA binding [IDA]
telomeric DNA binding [IDA]
transcription factor binding [TAS]

Gene Ontology Cellular Component

chromosome, telomeric region [ISO]

cytoplasm [ISO]

kinetochore [IDA]

nucleoplasm [ISO]

nucleus [IDA, ISO]

replication fork [IDA]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

Li J, Zhang W, Yang H, Howrigan DP, Wilkinson B, Souaiaia T, Evgrafov OV, Genovese G, Clementel VA, Tudor JC, Abel T, Knowles JA, Neale BM, Wang K, Sun F, Coba MP

The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]

Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]

Throughput

High Throughput

Additional Notes

e14

Curated By

BioGRID