HUWE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
OGT
Gene Ontology Biological Process
- apoptotic process [ISO]
- cellular response to glucose stimulus [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to retinoic acid [ISO]
- circadian regulation of gene expression [IMP]
- glucosamine metabolic process [ISO]
- histone H3-K4 trimethylation [ISO]
- histone H4-K16 acetylation [ISO]
- histone H4-K5 acetylation [ISO]
- histone H4-K8 acetylation [ISO]
- intracellular distribution of mitochondria [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cellular response to hypoxia [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of peptidyl-threonine phosphorylation [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein targeting to membrane [ISO]
- negative regulation of protein ubiquitination [IDA]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell size [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of histone H3-K27 methylation [ISO]
- positive regulation of histone H3-K4 methylation [ISO]
- positive regulation of protein localization to nucleus [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein O-linked glycosylation [IDA, ISO, ISS, TAS]
- protein heterotrimerization [ISO]
- protein homotrimerization [ISO]
- regulation of Rac protein signal transduction [ISO]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [IMP]
- regulation of glycolytic process [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- N-acetyltransferase activity [TAS]
- catalytic activity [ISS]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- monosaccharide binding [ISO]
- peptide binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- protein N-acetylglucosaminyltransferase activity [ISO]
- protein O-GlcNAc transferase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription factor binding [ISO]
- N-acetyltransferase activity [TAS]
- catalytic activity [ISS]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO]
- histone acetyltransferase activity (H4-K5 specific) [ISO]
- histone acetyltransferase activity (H4-K8 specific) [ISO]
- monosaccharide binding [ISO]
- peptide binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- protein N-acetylglucosaminyltransferase activity [ISO]
- protein O-GlcNAc transferase activity [IDA, IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- cytoplasm [ISO, TAS]
- cytosol [ISO]
- euchromatin [ISO]
- histone acetyltransferase complex [ISO]
- intracellular [TAS]
- microtubule organizing center [ISO]
- mitochondrion [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO, TAS]
- plasma membrane [ISO]
- zymogen granule [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
HUWE1 OGT | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.737 | BioGRID | 2664310 |
Curated By
- BioGRID