A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Nucleosome eviction in mitosis assists condensin loading and chromosome condensation.

Toselli-Mollereau E, Robellet X, Fauque L, Lemaire S, Schiklenk C, Klein C, Hocquet C, Legros P, N'Guyen L, Mouillard L, Chautard E, Auboeuf D, Haering CH, Bernard P

Condensins associate with DNA and shape mitotic chromosomes. Condensins are enriched nearby highly expressed genes during mitosis, but how this binding is achieved and what features associated with transcription attract condensins remain unclear. Here, we report that condensin accumulates at or in the immediate vicinity of nucleosome-depleted regions during fission yeast mitosis. Two transcriptional coactivators, the Gcn5 histone acetyltransferase and ... [more]

EMBO J. Jul. 15, 2016; 35(14);1565-81 [Pubmed: 27266525]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
TOP2 GCN5	Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.	Nguyen TT (2015)	Low	-	BioGRID	2335094

Curated By

BioGRID

Interaction Summary

TOP2

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, IGI, IMP]

Gene Ontology Cellular Component

GCN5