FANCD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TFAM
Gene Ontology Biological Process
- chromatin remodeling [IBA]
- mitochondrial respiratory chain complex assembly [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription, DNA-templated [IBA, TAS]
- transcription from mitochondrial promoter [ISO]
- transcription initiation from mitochondrial promoter [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- DNA binding, bending [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin binding [IBA, ISO]
- heat shock protein binding [ISO]
- mitochondrial light strand promoter sense binding [ISO]
- poly(A) RNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- chromatin binding [IBA, ISO]
- heat shock protein binding [ISO]
- mitochondrial light strand promoter sense binding [ISO]
- poly(A) RNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Throughput
- High Throughput
Curated By
- BioGRID