smc4, SPBC146.03c
condensin complex subunit Cut3
GO Process (3)
GO Function (1)
GO Component (5)
Schizosaccharomyces pombe (972h)


ada3, kap1, SPBC28F2.10c
SAGA complex subunit Ngg1
GO Process (3)
GO Function (0)
GO Component (3)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Nucleosome eviction in mitosis assists condensin loading and chromosome condensation.

Toselli-Mollereau E, Robellet X, Fauque L, Lemaire S, Schiklenk C, Klein C, Hocquet C, Legros P, N'Guyen L, Mouillard L, Chautard E, Auboeuf D, Haering CH, Bernard P

Condensins associate with DNA and shape mitotic chromosomes. Condensins are enriched nearby highly expressed genes during mitosis, but how this binding is achieved and what features associated with transcription attract condensins remain unclear. Here, we report that condensin accumulates at or in the immediate vicinity of nucleosome-depleted regions during fission yeast mitosis. Two transcriptional coactivators, the Gcn5 histone acetyltransferase and ... [more]

EMBO J. Jul. 15, 2016; 35(14);1565-81 [Pubmed: 27266525]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID