FANCD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPD1
Gene Ontology Biological Process
- B cell activation [ISO]
- B cell cytokine production [ISO]
- B cell proliferation [ISO]
- MyD88-dependent toll-like receptor signaling pathway [ISO]
- T cell activation [IDA, IGI, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- chaperone mediated protein folding requiring cofactor [ISO]
- detection of misfolded protein [ISO]
- isotype switching to IgG isotypes [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of T cell activation [IDA, ISO]
- positive regulation of T cell mediated immune response to tumor cell [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-alpha production [IDA, ISO]
- positive regulation of interferon-gamma production [IDA, IGI, ISO]
- positive regulation of interleukin-10 production [ISO]
- positive regulation of interleukin-12 production [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of macrophage activation [ISO]
- protein refolding [ISO]
- protein stabilization [ISO]
- response to unfolded protein [ISO]
Gene Ontology Molecular Function- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [ISO]
- lipopolysaccharide binding [IDA, ISO]
- misfolded protein binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
- chaperone binding [ISO]
- double-stranded RNA binding [ISO]
- insulin binding [ISO]
- lipopolysaccharide binding [IDA, ISO]
- misfolded protein binding [ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protease binding [ISO]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell surface [ISO]
- coated pit [ISO]
- coated vesicle [ISO]
- cyclin-dependent protein kinase activating kinase holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- early endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [IDA]
- lipopolysaccharide receptor complex [ISO]
- membrane [ISO]
- membrane raft [ISO]
- mitochondrial crista [ISO]
- mitochondrial inner membrane [IDA]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
- secretory granule [IDA, ISO]
- zymogen granule [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
FANCD2 HSPD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | High | - | BioGRID | - |
Curated By
- BioGRID