BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ATP2A2
9530097L16Rik, D5Wsu150e, SERCA2, SERCA2B, mKIAA4195
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
GO Process (22)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- ER-nucleus signaling pathway [IMP]
- T-tubule organization [IMP]
- calcium ion import into sarcoplasmic reticulum [ISO]
- calcium ion transmembrane transport [IDA, ISO]
- calcium ion transport [ISO]
- calcium ion transport from cytosol to endoplasmic reticulum [ISO]
- cellular calcium ion homeostasis [IDA, IGI, IMP, ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- negative regulation of heart contraction [IGI]
- organelle organization [IMP]
- positive regulation of endoplasmic reticulum calcium ion concentration [ISO]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [IMP]
- regulation of cardiac muscle cell action potential involved in regulation of contraction [ISO]
- regulation of cardiac muscle cell membrane potential [ISO]
- regulation of cardiac muscle contraction by calcium ion signaling [ISO]
- regulation of muscle contraction [TAS]
- regulation of the force of heart contraction [IGI]
- relaxation of cardiac muscle [ISO]
- response to peptide hormone [ISO]
- sarcoplasmic reticulum calcium ion transport [IMP, ISO]
- transition between fast and slow fiber [IDA]
Gene Ontology Molecular Function- ATP binding [ISO]
- S100 protein binding [ISO]
- calcium ion binding [ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [ISO]
- enzyme binding [IPI, ISO]
- lutropin-choriogonadotropic hormone receptor binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- ATP binding [ISO]
- S100 protein binding [ISO]
- calcium ion binding [ISO]
- calcium-transporting ATPase activity [IDA, ISO]
- calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential [ISO]
- enzyme binding [IPI, ISO]
- lutropin-choriogonadotropic hormone receptor binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
Gene Ontology Cellular Component
- calcium ion-transporting ATPase complex [ISO]
- cell [IGI]
- endoplasmic reticulum [IDA, ISO]
- endoplasmic reticulum membrane [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- intercalated disc [ISO]
- longitudinal sarcoplasmic reticulum [ISO]
- membrane [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
- ribbon synapse [IDA]
- sarcoplasmic reticulum [IDA, ISO, TAS]
- vesicle membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID