BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ATP2A1
SERCA1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
GO Process (20)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- apoptotic mitochondrial changes [ISO]
- calcium ion import [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- carbohydrate derivative transport [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISO]
- maintenance of mitochondrion location [ISO]
- negative regulation of endoplasmic reticulum calcium ion concentration [ISO]
- negative regulation of striated muscle contraction [ISO]
- nucleotide transmembrane transport [ISO]
- positive regulation of endoplasmic reticulum calcium ion concentration [ISO]
- positive regulation of fast-twitch skeletal muscle fiber contraction [ISO]
- positive regulation of mitochondrial calcium ion concentration [ISO]
- regulation of muscle contraction [TAS]
- regulation of striated muscle contraction [ISO]
- relaxation of skeletal muscle [ISO]
- response to endoplasmic reticulum stress [ISO]
- response to peptide hormone [ISO]
- sarcoplasmic reticulum calcium ion transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID