BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ATP1B1
Atp4b, Atpb, Atpb-1, NKbeta1
ATPase, Na+/K+ transporting, beta 1 polypeptide
GO Process (26)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- blastocyst development [IMP]
- cardiac muscle contraction [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular potassium ion homeostasis [ISO]
- cellular sodium ion homeostasis [ISO]
- membrane repolarization [ISO]
- metal ion transport [ISO]
- positive regulation of ATP catabolic process [ISO]
- positive regulation of ATPase activity [ISO]
- positive regulation of calcium:sodium antiporter activity [IMP]
- positive regulation of potassium ion import [ISO]
- positive regulation of potassium ion transmembrane transporter activity [ISO]
- positive regulation of sodium ion export from cell [ISO]
- potassium ion import [IC, ISO]
- potassium ion transport [ISO]
- protein localization to plasma membrane [ISO]
- protein stabilization [IMP, ISO]
- regulation of calcium ion transmembrane transport [IMP]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of gene expression [IMP]
- relaxation of cardiac muscle [IMP]
- response to hypoxia [ISO]
- sodium ion export from cell [IC, ISO]
- sodium ion transmembrane transport [ISO]
- sodium ion transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID