BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NPM1
B23, NO38, Npm, RP23-323L8.2
nucleophosmin 1
GO Process (39)
GO Function (18)
GO Component (16)
Gene Ontology Biological Process
- DNA repair [ISO]
- cell aging [ISO]
- cell growth [IDA]
- cell volume homeostasis [IDA, IMP]
- centrosome cycle [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of centrosome duplication [ISO]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [ISO]
- nucleocytoplasmic transport [IDA, ISO]
- nucleosome assembly [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cellular biosynthetic process [IDA, IMP]
- positive regulation of centrosome duplication [IGI]
- positive regulation of protein kinase activity [IDA]
- positive regulation of translation [ISO]
- protein destabilization [IMP]
- protein homooligomerization [ISO]
- protein localization [IMP, ISO]
- protein oligomerization [ISO]
- rRNA export from nucleus [IDA, IMP]
- regulation of DNA damage response, signal transduction by p53 class mediator [IGI]
- regulation of cell cycle [IMP]
- regulation of centriole replication [ISO]
- regulation of centrosome duplication [IMP]
- regulation of eIF2 alpha phosphorylation by dsRNA [ISO]
- regulation of endodeoxyribonuclease activity [ISO]
- regulation of endoribonuclease activity [ISO]
- regulation of neuron apoptotic process [ISO]
- response to stress [ISO]
- ribosomal large subunit biogenesis [IDA, IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit biogenesis [IDA, IMP]
- ribosomal small subunit export from nucleus [IDA]
Gene Ontology Molecular Function- DNA binding [ISO]
- NF-kappaB binding [ISO]
- RNA binding [IDA, ISO]
- Tat protein binding [ISO]
- enzyme binding [ISO]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO]
- rRNA binding [IDA]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO]
- DNA binding [ISO]
- NF-kappaB binding [ISO]
- RNA binding [IDA, ISO]
- Tat protein binding [ISO]
- enzyme binding [ISO]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO]
- rRNA binding [IDA]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- cell [IMP]
- centrosome [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- focal adhesion [ISO]
- granular component [IDA]
- intracellular [IMP]
- large ribosomal subunit [IDA]
- membrane [ISO]
- nuclear speck [IDA]
- nucleolus [IDA, ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- ribonucleoprotein complex [ISO]
- small ribosomal subunit [IDA]
- spindle pole centrosome [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID