BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CTNNA1
2010010M04Rik, AA517462, AI988031, Catna1
catenin (cadherin associated protein), alpha 1
GO Process (15)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- apical junction assembly [IMP]
- cellular protein localization [IMP]
- cellular response to indole-3-methanol [ISO]
- epithelial cell-cell adhesion [IMP]
- establishment or maintenance of cell polarity [IMP]
- gap junction assembly [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell motility [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of integrin-mediated signaling pathway [IMP]
- negative regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of smoothened signaling pathway [IGI]
- protein heterooligomerization [ISO]
- regulation of cell proliferation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID