BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LONP1
1200017E13Rik, LON, Prss15
lon peptidase 1, mitochondrial
GO Process (10)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [IDA, ISO]
- cellular protein complex assembly [ISO]
- cellular response to oxidative stress [ISO]
- chaperone-mediated protein complex assembly [IBA]
- misfolded or incompletely synthesized protein catabolic process [IBA]
- mitochondrion organization [IBA, ISO]
- oxidation-dependent protein catabolic process [ISO]
- protein homooligomerization [ISO]
- proteolysis [IDA, ISO]
- proteolysis involved in cellular protein catabolic process [ISO]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATP-dependent peptidase activity [IDA, ISO]
- ATPase activity [IDA]
- DNA polymerase binding [ISO]
- G-quadruplex DNA binding [ISO]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA, ISO]
- mitochondrial light strand promoter sense binding [IDA]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATP-dependent peptidase activity [IDA, ISO]
- ATPase activity [IDA]
- DNA polymerase binding [ISO]
- G-quadruplex DNA binding [ISO]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA, ISO]
- mitochondrial light strand promoter sense binding [IDA]
- sequence-specific DNA binding [ISO]
- single-stranded DNA binding [IDA]
- single-stranded RNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID