BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
VCP
3110001E05, CDC48, p97, p97/VCP, RP23-124L1.5
valosin containing protein
GO Process (19)
GO Function (13)
GO Component (15)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- ER to Golgi vesicle-mediated transport [ISO]
- ER-associated ubiquitin-dependent protein catabolic process [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- aggresome assembly [IGI]
- cellular response to DNA damage stimulus [ISO]
- double-strand break repair [ISO]
- positive regulation of Lys63-specific deubiquitinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein K63-linked deubiquitination [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein N-linked glycosylation via asparagine [ISO]
- protein hexamerization [ISO]
- protein homooligomerization [ISO]
- protein ubiquitination [ISO]
- retrograde protein transport, ER to cytosol [ISO]
- translesion synthesis [ISO]
- ubiquitin-dependent protein catabolic process [IGI]
Gene Ontology Molecular Function- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- deubiquitinase activator activity [ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- ubiquitin-specific protease binding [ISO]
- ADP binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- deubiquitinase activator activity [ISO]
- identical protein binding [ISO]
- poly(A) RNA binding [ISO]
- polyubiquitin binding [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- ubiquitin-specific protease binding [ISO]
Gene Ontology Cellular Component
- Hrd1p ubiquitin ligase complex [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endoplasmic reticulum [ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- intracellular membrane-bounded organelle [ISO]
- lipid particle [ISO]
- myelin sheath [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- proteasome complex [ISO]
- protein complex [IPI]
- site of double-strand break [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID