BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
LRP1
A2mr, AI316852, CD91, Lrp, b2b1554Clo
low density lipoprotein receptor-related protein 1
GO Process (17)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- aorta morphogenesis [IMP]
- apoptotic cell clearance [IMP]
- beta-amyloid clearance [IMP]
- cell proliferation [ISO]
- cholesterol metabolic process [IMP]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of smooth muscle cell migration [IMP]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of lipid transport [IMP]
- positive regulation of protein transport [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cholesterol transport [IMP]
- regulation of phospholipase A2 activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID