BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HCK
AI849071, Bmk
hemopoietic cell kinase
GO Process (18)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- cell differentiation [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cytoskeleton organization [IBA]
- defense response to Gram-positive bacterium [IGI]
- innate immune response [IBA]
- negative regulation of apoptotic process [IBA, ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- phagocytosis [IMP]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of cell proliferation [ISO]
- protein autophosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of cell shape [ISO]
- regulation of phagocytosis [IBA, ISO]
- regulation of podosome assembly [IBA, ISO]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID