BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HRAS
H-ras, Ha-ras, Harvey-ras, Hras-1, Hras1, Kras2, c-H-ras, c-Ha-ras, c-rasHa, ras
Harvey rat sarcoma virus oncogene
GO Process (33)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Ras protein signal transduction [ISO, TAS]
- apoptotic process [ISO]
- cell aging [IDA]
- cell cycle arrest [ISO]
- cell proliferation [IPI]
- cellular senescence [ISO]
- endocytosis [IDA]
- intrinsic apoptotic signaling pathway [IGI, IMP]
- mitotic cell cycle checkpoint [ISO]
- negative regulation of Rho GTPase activity [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of neuron apoptotic process [IDA, IGI]
- positive regulation of DNA replication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of wound healing [ISO]
- protein heterooligomerization [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- small GTPase mediated signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID