BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAP1A
AI848598, G-22K, Krev-1, Rap1
RAS-related protein-1a
GO Process (15)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- Rap protein signal transduction [ISO]
- cellular response to cAMP [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- establishment of endothelial barrier [ISO]
- negative regulation of synaptic vesicle exocytosis [IGI]
- nerve growth factor signaling pathway [ISO]
- positive regulation of ERK1 and ERK2 cascade [IGI, ISO]
- positive regulation of Rap GTPase activity [ISO]
- positive regulation of neuron projection development [IDA, ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of vasculogenesis [IMP]
- protein transport [ISO]
- regulation of cell junction assembly [ISO]
- small GTPase mediated signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID