BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KRAS
AI929937, K-ras, Ki-ras, Kras-2, Kras2, p21B, ras, RP24-359O2.1
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
GO Process (18)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [IGI]
- Ras protein signal transduction [IGI, TAS]
- actin cytoskeleton organization [IGI]
- cytokine-mediated signaling pathway [ISO]
- epithelial tube branching involved in lung morphogenesis [IDA, IGI]
- negative regulation of cell differentiation [IDA]
- negative regulation of neuron apoptotic process [IGI]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of Rac protein signal transduction [IGI]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [IGI]
- regulation of synaptic transmission, GABAergic [IGI]
- striated muscle cell differentiation [IGI]
- visual learning [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID