BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BNIP3
Nip3
BCL2/adenovirus E1B interacting protein 3
GO Process (26)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- apoptotic process [ISO]
- autophagic cell death [ISO]
- brown fat cell differentiation [IDA]
- cell death [ISO]
- cellular response to cobalt ion [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to hypoxia [ISO]
- defense response to virus [ISO]
- granzyme-mediated apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway [IGI, IMP]
- intrinsic apoptotic signaling pathway in response to hypoxia [ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrial outer membrane permeabilization [IBA, ISO]
- mitochondrial protein catabolic process [ISO]
- negative regulation of membrane potential [ISO]
- negative regulation of mitochondrial fusion [ISO]
- neuron apoptotic process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of mitochondrial fission [ISO]
- positive regulation of programmed cell death [IBA, ISO]
- positive regulation of protein complex disassembly [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of mitochondrial membrane permeability [ISO]
- response to hypoxia [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [ISO]
- dendrite [ISO]
- endoplasmic reticulum [IBA]
- integral component of mitochondrial outer membrane [ISO]
- intracellular [IGI]
- mitochondrial membrane [IDA, ISO]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear envelope [IBA, ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID