BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GRM5
6430542K11Rik, AI850523, Glu5R, Gprc1e, mGluR5, mGluR5b
glutamate receptor, metabotropic 5
GO Process (15)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO]
- activation of MAPKKK activity [ISO]
- cognition [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [ISO]
- learning [IMP]
- locomotory behavior [IGI, IMP]
- negative regulation of locomotion [ISO]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of long-term neuronal synaptic plasticity [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA, ISO]
- protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of synaptic transmission, glutamatergic [IBA]
- regulation of transcription, DNA-templated [ISO]
- synaptic transmission [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID