BAIT
CHEK2
CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, RP11-436C9.1
checkpoint kinase 2
GO Process (17)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- DNA damage checkpoint [TAS]
- DNA damage induced protein phosphorylation [IMP]
- G2/M transition of mitotic cell cycle [IMP]
- cellular protein catabolic process [IMP]
- cellular response to DNA damage stimulus [IMP, TAS]
- double-strand break repair [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- protein stabilization [IDA]
- regulation of protein catabolic process [IMP]
- regulation of transcription, DNA-templated [IDA]
- replicative senescence [NAS]
- signal transduction in response to DNA damage [IDA]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
- spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WRN
RECQ3, RECQL2, RECQL3
Werner syndrome, RecQ helicase-like
GO Process (21)
GO Function (17)
GO Component (4)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA duplex unwinding [IDA, IMP]
- DNA metabolic process [IDA]
- DNA replication [IMP]
- DNA synthesis involved in DNA repair [IDA]
- aging [NAS]
- base-excision repair [IDA]
- cell aging [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to gamma radiation [IDA]
- cellular response to starvation [IDA]
- double-strand break repair [IMP]
- multicellular organismal aging [IMP]
- nucleic acid phosphodiester bond hydrolysis [IDA]
- nucleolus to nucleoplasm transport [IDA]
- positive regulation of hydrolase activity [IDA]
- regulation of apoptotic process [IGI]
- replication fork processing [IDA, IMP]
- response to UV-C [IDA]
- response to oxidative stress [IDA]
- telomere maintenance [IMP]
Gene Ontology Molecular Function- 3'-5' DNA helicase activity [IDA]
- 3'-5' exonuclease activity [IDA]
- ATP-dependent DNA helicase activity [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA helicase activity [IDA, IMP]
- G-quadruplex DNA binding [IDA]
- Y-form DNA binding [IDA]
- bubble DNA binding [IDA]
- exonuclease activity [IDA]
- four-way junction helicase activity [IDA]
- helicase activity [IDA]
- magnesium ion binding [IDA]
- manganese ion binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IDA]
- 3'-5' DNA helicase activity [IDA]
- 3'-5' exonuclease activity [IDA]
- ATP-dependent DNA helicase activity [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA helicase activity [IDA, IMP]
- G-quadruplex DNA binding [IDA]
- Y-form DNA binding [IDA]
- bubble DNA binding [IDA]
- exonuclease activity [IDA]
- four-way junction helicase activity [IDA]
- helicase activity [IDA]
- magnesium ion binding [IDA]
- manganese ion binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (TSG) and ... [more]
Mol. Cell Aug. 04, 2016; 63(3);514-25 [Pubmed: 27453043]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507) [hela cell (BTO:0000567)]
Additional Notes
- CHEK1,CHEK2 double mutant as drug target
- Chemo-genetic screen with siRNAs
- Drug AZD7762
- HeLa cervical cancer cell line
Curated By
- BioGRID