BAIT
DHFR
DHFRP1, DYR
dihydrofolate reductase
GO Process (10)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [TAS]
- folic acid metabolic process [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- tetrahydrofolate metabolic process [IDA]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [TAS]
- nucleoplasm [TAS]
Homo sapiens
PREY
CDC73
C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
cell division cycle 73
GO Process (17)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- endodermal cell fate commitment [ISS]
- histone H2B ubiquitination [IDA]
- histone monoubiquitination [IDA]
- mRNA polyadenylation [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of mRNA 3'-end processing [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein destabilization [IMP]
- stem cell maintenance [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (TSG) and ... [more]
Mol. Cell Aug. 04, 2016; 63(3);514-25 [Pubmed: 27453043]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507) [hela cell (BTO:0000567)]
Additional Notes
- Chemo-genetic screen with siRNAs
- Drug: methotrexate
- HeLa cervical cancer cell line
Curated By
- BioGRID