MAP2K1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [IDA, TAS]
- activation of MAPKK activity [TAS]
- axon guidance [TAS]
- cell cycle arrest [IMP]
- cellular component movement [TAS]
- cellular senescence [IMP]
- chemotaxis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of cell proliferation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of gene expression [IMP]
- positive regulation of protein serine/threonine kinase activity [IDA]
- regulation of Golgi inheritance [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of stress-activated MAPK cascade [TAS]
- signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STK11
Gene Ontology Biological Process
- activation of protein kinase activity [IDA]
- anoikis [IMP]
- cell cycle arrest [IDA, TAS]
- energy reserve metabolic process [TAS]
- establishment of cell polarity [ISS]
- glucose homeostasis [ISS]
- insulin receptor signaling pathway [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IDA]
- negative regulation of cell growth [ISS]
- negative regulation of cell proliferation [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of cell growth [ISS]
- regulation of fatty acid biosynthetic process [TAS]
- response to ionizing radiation [ISS]
- small molecule metabolic process [TAS]
- vasculature development [ISS]
Gene Ontology Molecular Function
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (TSG) and ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: growth abnormality (HP:0001507) [hela cell (BTO:0000567)]
Additional Notes
- Chemo-genetic screen with siRNAs
- Drug: PD98059
- HeLa cervical cancer cell line
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STK11 MAP2K1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID