BAIT
FNTA
FPTA, PGGT1A, PTAR2
farnesyltransferase, CAAX box, alpha
GO Process (10)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- phototransduction, visible light [TAS]
- positive regulation of deacetylase activity [IDA]
- positive regulation of tubulin deacetylation [IDA]
- protein farnesylation [IDA]
- protein geranylgeranylation [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- rhodopsin mediated signaling pathway [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
XRCC3
CMM6
X-ray repair complementing defective repair in Chinese hamster cells 3
GO Process (8)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IMP]
- DNA recombination [TAS]
- DNA repair [IGI]
- cellular response to DNA damage stimulus [TAS]
- double-strand break repair via homologous recombination [IMP]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
- regulation of centrosome duplication [IMP]
- resolution of mitotic recombination intermediates [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (TSG) and ... [more]
Mol. Cell Aug. 04, 2016; 63(3);514-25 [Pubmed: 27453043]
Throughput
- High Throughput
Ontology Terms
- growth abnormality (HP:0001507) [hela cell (BTO:0000567)]
Additional Notes
- Chemo-genetic screen with siRNAs
- Drug target: RABGGTB,FNTA double mutant
- Drug: tipifarnib
- HeLa cervical cancer cell line
Curated By
- BioGRID