BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PTPN1
PTP-1B, PTP-HA2, PTP1B, RP23-58A8.1
protein tyrosine phosphatase, non-receptor type 1
GO Process (13)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- endoplasmic reticulum unfolded protein response [ISO]
- insulin receptor signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IGI]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IGI]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IGI]
- platelet-derived growth factor receptor-beta signaling pathway [IMP, ISO]
- protein dephosphorylation [IMP, ISO]
- regulation of endocytosis [ISO]
- regulation of hepatocyte growth factor receptor signaling pathway [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- regulation of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID